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KMID : 0616619980040010185
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Journal of Soonchunhyang Medical College
1998 Volume.4 No. 1 p.185 ~ p.191
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Effect of Mutation of β3-Adrenergic Receptor Gene on Visceral Adiposity and Lipid Metabolism
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Abstract
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The 03-adrenergic receptor is expressed in visceral adipose tissue in humans and is thought to contribute to the regulation of the resting metabolic rate and lipolysis. We studied the influence of a mutation in the N-adrenergic receptor gene (Trp64Arg) on body fat distribution, central obesity, lipid metabolism in 65 healthy young male adults.
One out of 65 subjects were homozygous (Arg/Arg) for the Trp64Arg mutation, 17 subjects were heterozygous (Trp/Arg), and 47 lacked the mutation (Trp/Trp). The body weight, height, body mass index, waist-to-hip ratio were similar between the subjects with- and without the mutation. Total body fat, abdominal fat amount, body fat distribution, serum total- and HDL-cholesterol, triglyceride, glucose, and insulin concentrations were also not different according to the presence or absence of the mutation.
These results suggested that Trp64Arg mutation in 03-adrenergic receptor gene is not a major contributing factor for central obesity or change in lipid metabolism in Korean young adults.
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KEYWORD
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